The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. We will utilize techniques from engineering, chemistry and biology to address these research areas, including chemical modifications to alter drug-material interactions, small molecule and macromolecule conjugates to direct cell fate, and multi-cellular tissue/disease systems for paracrine signaling and direct cell-cell interactions. My research is focused on biomaterials and their applications in tissue engineering and drug delivery. During my PhD, I worked with photo-crosslinked PEGDA hydrogel systems to study repair strategies for articular cartilage diseases. I also developed low density, bioactive-electrospun fiber scaffolds for repair of articular cartilage defects. My postdoctoral research used silk fibroin proteins from Bombyx mori silkworm cocoons for (1) drug delivery systems for oncology therapeutics and HIV treatment/prevention and (2) tissue regeneration of the kidney and pancreas. In the lab and the classroom, I truly enjoy teaching. I am especially excited to mentor students on their Major Qualifying Projects. I strive to ensure that students are able to (1) apply theoretical concepts to practical applications and (2) fully understand the tasks being performed.
The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. We will utilize techniques from engineering, chemistry and biology to address these research areas, including chemical modifications to alter drug-material interactions, small molecule and macromolecule conjugates to direct cell fate, and multi-cellular tissue/disease systems for paracrine signaling and direct cell-cell interactions. My research is focused on biomaterials and their applications in tissue engineering and drug delivery. During my PhD, I worked with photo-crosslinked PEGDA hydrogel systems to study repair strategies for articular cartilage diseases. I also developed low density, bioactive-electrospun fiber scaffolds for repair of articular cartilage defects. My postdoctoral research used silk fibroin proteins from Bombyx mori silkworm cocoons for (1) drug delivery systems for oncology therapeutics and HIV treatment/prevention and (2) tissue regeneration of the kidney and pancreas. In the lab and the classroom, I truly enjoy teaching. I am especially excited to mentor students on their Major Qualifying Projects. I strive to ensure that students are able to (1) apply theoretical concepts to practical applications and (2) fully understand the tasks being performed.
Scholarly Work
Yavuz B, Zeki J, Harrington K, Coburn J, Ikegaki N, Kaplan D, Chiu B. (2019) Silk reservoirs for local delivery of cisplatin for neuroblastoma treatment: In vitro and in vivo evaluation. Journal of Pharmaceutical Sciences. 108(8):2748-2755. 2019
Gupta AK, Sarkar P, Coburn JM, Davis-Knowlton J, Palma EK, Kaplan DL, Oxburgh L. (2019) Scaffolding kidney organoids on silk. Journal of Tissue Engineering and Regenerative. 108(8):2748-2755. 2019
Yavuz B, Zeki J, Coburn JM, Ikegaki N, Levitin D, Kaplan DL, Chiu B. (2018) In vitro and in vivo evaluation of etoposide-silk wafers for neuroblastoma treatment. Journal of Controlled Release. 3:162-171. 2018
Ashari N, Pang HW, Simon T, Xiong Y, Coburn JM, Bromberg JS, Kaplan DL, McLenithan J, Fontaine MJ. (2018). Silk fibroin preserves beta cell function under inflammatory stress while stimulating islet cell surface GLUT2 expression. Cell Immunology. 329:10-16. 2018
Montalbán MG, Coburn JM, Lozano-Pérez AA, Cénis JL, Víllora G, Kaplan DL. (2018) Production of curcumin-loaded silk fibroin nanoparticles for cancer therapy. Journal of Nanotechnology. 8(2):126. 2018
Coburn J, Harris J, Cunningham R, Zeki J, Kaplan DL, Chiu B. Manipulation of variables in local controlled release vincristine treatment in neuroblastoma. (2017) Journal of Pediatric Surgery. 52(12):2061-2065.
Patents