My research is in the broad, interdisciplinary field of synthetic biology, which applies engineering principles to biology. Within this field, we apply chemical engineering tenets to reprogram the DNA of yeasts, bacteria, and fungi so their metabolism produces interesting molecules. By treating these cells as "chemical factories," we can approach and solve problems in biofuels, biomaterials, and biosensors from a chemical engineer's point of view. Our strengths are in the disciplines of metabolic engineering, protein engineering, and systems biology, which we use to construct novel synthetic microbes. We collaborate with researchers across WPI, other institutions, and biotechnology companies to solve problems by engineering biology.
In the classroom, I train students within the unique project-based learning approach at WPI. To me, there is no greater reward than teaching a new generation of problem solvers that will make meaningful contributions to all areas of chemical engineering, and beyond. This is enabled by WPI’s emphasis on technology & society, which creates an environment where students can attain technical proficiency, study social impacts, and develop an entrepreneurial mindset. Therefore, I integrate value creation and social consciousness into my biochemical engineering courses.
Visit Digital WPI to view student projects advised by Professor Young.
My research is in the broad, interdisciplinary field of synthetic biology, which applies engineering principles to biology. Within this field, we apply chemical engineering tenets to reprogram the DNA of yeasts, bacteria, and fungi so their metabolism produces interesting molecules. By treating these cells as "chemical factories," we can approach and solve problems in biofuels, biomaterials, and biosensors from a chemical engineer's point of view. Our strengths are in the disciplines of metabolic engineering, protein engineering, and systems biology, which we use to construct novel synthetic microbes. We collaborate with researchers across WPI, other institutions, and biotechnology companies to solve problems by engineering biology.
In the classroom, I train students within the unique project-based learning approach at WPI. To me, there is no greater reward than teaching a new generation of problem solvers that will make meaningful contributions to all areas of chemical engineering, and beyond. This is enabled by WPI’s emphasis on technology & society, which creates an environment where students can attain technical proficiency, study social impacts, and develop an entrepreneurial mindset. Therefore, I integrate value creation and social consciousness into my biochemical engineering courses.
Visit Digital WPI to view student projects advised by Professor Young.
SDG 3: Good Health & Well-Being
SDG 3: Good Health & Well-Being - Ensure healthy lives and promote well-being for all at all ages
SDG 4: Quality Education
SDG 4: Quality Education - Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all
SDG 7: Affordable and Clean Energy
SDG 7: Affordable and Clean Energy - Ensure access to affordable, reliable, sustainable and modern energy for all
SDG 8: Decent Work and Economic Growth
SDG 8: Decent Work and Economic Growth - Promote sustained, inclusive and sustainable economic growth, full and productive employment and decent work for all
SDG 9: Industry, Innovation, and Infrastructure
SDG 9: Industry, Innovation, and Infrastructure - Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
SDG 11: Sustainable Cities and Communities
SDG 11: Sustainable Cities and Communities - Make cities and human settlements inclusive, safe, resilient and sustainable
Scholarly Work
Professor Young's research focuses on non-model microbial hosts, bio-security, and genomics.
Featured works:
Collins, J. H., Keating, K. W., Jones, T. R., Balaji, S., Marsan, C. B., Çomo, M., Newlon, Z. J., Mitchell, T., Bartley, B., Adler, A., Roehner, N., & Young, E. M. (2021) Engineered yeast genomes accurately assembled from pure and mixed samples. Nature Communicaitons, 12(1), 1485. https://doi.org/10.1038/s41467-021-21656-9
Mante, J., Hao, Y., Jett, J., Joshi, U., Keating, K., Lu, X., Nakum, G., Rodriguez, N. E., Tang, J., Terry, L., Wu, X., Yu, E., Downie, J.S., McInnes, B. T., Nguyen, M. H., Sepulvado, B., Young, E. M. & Myers, C. J.(2021) Synthetic Biology Knowledge System. ACS Synthetic Biology, 10(9), 2276-2285. https://doi.org/10.1021/acssynbio.1c00188
Brzycki, C. M., Young, E. M. & Roberts, S. C.(2021) Secondary Metabolite Production in Plant Cell Culture: A New Epigenetic Frontier. In S. Malik (Ed), Exploring Plant Cells for the Production of Compounds of Interest, (1 ed., pp. 1-37). https://doi.org/10.1007/978-3-030-58271-5_1
Chen, Y., Zhang, S., Young, E.M. et al.(2020) Genetic circuit design automation for yeast.. Nature Microbiology, 5, 1349-1360. https://doi.org/10.1038/s41564-020-0757-2
Keating, K.W., & Young, M. E. (2019) Synthetic biology for bio-derived structural materials. Current Opinion in Chemical Engineering, 24, 107-114. https://doi.org/10.1016/j.coche.2019.03.002
Collins, J. H., & Young, E.M. (2018) Genetic engineering of host organisms for pharmaceutical synthesis. Current Opinion in Biotechnology, 53, 191-200. https://doi.org/10.1016/j.copbio.2018.02.001
Patents:
Young, E. M., Gordon, D. B., Voight, C. (2017) Composability and Design of Parts for Large Scale Pathway Engineering in Yeast. (U.S. Patent No. 2017015947A9). U.S. Patent and Trademark Office. Filed.
Alper, H., Young, E. M. & Lee, S. (2014) Engineered Xylose Transporters with Reduced Glucose Inhibition. (U.S. Patent No. 9,695,223). U.S. Patent and Trademark Office.
Alper, H. & Young, E. M. (2013) Methods for Engineering Sugar Transporter Preferences. (U.S. Patent No. 9,926,347). U.S. Patent and Trademark Office.
National Science Foundation